Enhance Retention of Polar/Ionic Compounds: Allow separation of analytes that would otherwise elute too quickly in reversed-phase HPLC.

Form Ion Pairs with Charged Analytes: Improve interaction with the non-polar stationary phase, leading to better separation.

Versatile Reagent Types (Anionic/Cationic): Suitable for both acidic and basic compounds depending on their charge.

Improve Peak Shape and Resolution: Yield sharper, more symmetrical peaks, reducing tailing and overlap.

Extend the Use of Reversed Phase Columns: Eliminate the need for ion-exchange columns for ionic compounds.

Compatible with Gradient Elution: Allow flexibility in method development and faster analysis times.

Applicable Across Various Industries: Useful in pharmaceuticals, food testing, environmental analysis, and clinical research.